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Your Parkinson's News Update for the Week of 5.4.20

Monday May 04, 2020
New Evidence that Higher Caffeine and Urate Levels are Protective Against Parkinson's
Journal of Parkinson's Disease via MedicalXpress
"Two purines, caffeine and urate, have been associated with a reduced risk of Parkinson's in multiple study groups and populations. Analysis of data from the Harvard Biomarkers Study shows that lower levels of caffeine consumption and lower blood urate are inversely associated with Parkinson's, strengthening the links between caffeine intake and urate levels and Parkinson's, reports a study in the Journal of Parkinson's Disease."
Parkinson’s: Autoimmune Attack May Start Years Before Diagnosis
Nature Communications via Medical News Today
"A new study — spearheaded by researchers from the La Jolla Institute for Immunology (LJI), in California — adds to evidence that the immune system may be responsible for the damage to nerve cells. The findings offer hope that doctors may be able to diagnose the disease earlier and that immunosuppressant treatment could slow, or even prevent, the loss of dopamine cells."
Parkinson's Dyskinesia Mechanism Explained
Science Advances via Medical Xpress
"Dopamine replacement therapy makes Parkinson's symptoms much better at first, but eventually treatment gives way to uncontrollable, jerky body movements. But why? New research shows that underlying this development is the therapy's unintended boost of a protein with the unwieldy name Ras-guanine nucleotide-releasing factor 1, or RasGRP1 for short. This boost in RasGRP1 produces a cascade of effects which lead to abnormal, involuntary movements known as LID, or L-DOPA-induced dyskinesia, says co-lead author Srinivasa Subramaniam, Ph.D., associate professor of neuroscience at Scripps Research, Florida."