News ArchivesRead News
Austrian Biotech Firm's Parkinson's Vaccine
Wednesday July 30, 2014
The Local - An Austrian company has developed a potentially viable vaccine for early-stage Parkinson's disease. The treatment, which is designed to slow or even stop progression of the disease, has undergone a Phase I clinical trial, from which data was released on Thursday in New York.
The treatment is based on a candidate vaccine known as PD01A, which lowers levels of alpha-synuclein. This is a brain protein which is believed to play an important role in maintaining a supply of synaptic vesicles in presynaptic terminals, as well as helping to regulate the release of dopamine, a type of neurotransmitter that is critical for controlling the start and stop of voluntary and involuntary movements.
The trial was conducted at the Confraternität Privatklinik Josefstadt in Vienna and involved up to 32 patients.
The preliminary results of the trial showed that the vaccine was well tolerated and safe, that it induced an immune response, and that the immune response appeared to be improving function.
"If you add all this together, I think we have the first evidence that would tell us that these findings are compatible with what we look for with disease modification," Achim Schneeberger, MD, chief medical officer of AFFiRiS, the Austrian pharmaceutical company developing the drug, told a press conference where the initial results were released.
AFFiRiS AG employs 100 highly-qualified staff at the Campus Vienna Biocenter in Vienna, Austria where the vaccine was developed. In addition to its work on the Parkinson's vaccine, the company has been developing peptide vaccines for Alzheimer's disease and Atherosclerosis.
In part, the research was funded by the Michael J. Fox Foundation to the tune of $1.5 million (€1.12 million). The foundation is dedicated to accelerating a cure for Parkinson's disease and improved therapies for those living with the condition today. Its founder, Michael J. Fox, is a well-known Canadian-American actor who is a high-profile victim of the disease.
(30 July 2014). The Local. Austrian Biotech Firm's Parkinson's Vaccine. http://www.thelocal.at/20140730/austrian-biotech-to-release-parkinsons-vaccine-data
Recent NewsAug 14 - 16 Tips to Increase Your Mobility Confidence While Living With Parkinson’s Disease
Aug 10 - Boxers are fighting back against Parkinson’s
Aug 7 - The Importance of Oral Health in Parkinson’s Disease
Aug 7 - Researchers Gain Better Insight Into Alpha-Synuclein’s Role in Parkinson’s Disease
Jul 31 - New Digital Cognitive Assessment Tool Receives Positive FDA Review
Jul 20 - Parkinson’s DREAM Challenge Uses Mobile Sensor Data to Monitor Health Based on Movement
Jul 19 - What Young-onset Parkinson’s Can Look Like
Jul 7 - Parkinson’s Patients Have a Higher Risk of Developing Melanoma — and Vice Versa, Study Finds
Jun 27 - The rogue protein behind Parkinson’s disease may also protect your gut
Jun 26 - Do Statins Increase Risk of Parkinson’s Disease? Some Researchers Think So
Jun 22 - A Confused Immune System Could Be Behind Parkinson's Disease
Jun 21 - Predicting cognitive deficits in people with Parkinson’s disease
Jun 20 - Gym offers classes in noncontact boxing for Parkinson’s patients
Jun 19 - Human Limitations Could Prevent Us From Advancing in Science. AI Could Help.
Jun 13 - Brain Cell Transplants Are Being Tested Once Again For Parkinson's
Jun 12 - Smell Test May Sniff Out Oncoming Parkinson's and Alzheimer's
Jun 8 - Smartphones Track Motor Function in Parkinson's Disease
Jun 8 - GKC Enrolls First Patient in Personal KinetiGraph Trial as Part of NPF’s Parkinson’s Outcomes Project
Jun 8 - Low-fat dairy intake may raise Parkinson's risk
Jun 6 - Patient Voices: Parkinson's Disease