News ArchivesRead News
MRI Brain Scans Detect People with Early Parkinson's
Monday July 07, 2014
Domain-B - Oxford University researchers funded by Parkinson's UK have developed a simple and quick MRI technique that offers promise for early diagnosis of Parkinson's disease.
The team demonstrated that their new MRI approach can detect people who have early-stage Parkinson's disease with 85 per cent accuracy, according to research published in Neurology, the medical journal of the American Academy of Neurology.
"At the moment we have no way to predict who is at risk of Parkinson's disease in the vast majority of cases," says Dr Clare Mackay of the department of psychiatry at Oxford University, one of the joint lead researchers. "We are excited that this MRI technique might prove to be a good marker for the earliest signs of Parkinson's. The results are very promising."
Claire Bale, research communications manager at Parkinson's UK, explains, "This new research takes us one step closer to diagnosing Parkinson's at a much earlier stage – one of the biggest challenges facing research into the condition. By using a new, simple scanning technique the team at Oxford University have been able to study levels of activity in the brain which may suggest that Parkinson's is present. One person every hour is diagnosed with Parkinson's in the UK, and we hope that the researchers are able to continue to refine their test so that it can one day be part of clinical practice."
The researchers from the Oxford Parkinson's Disease Centre also received support from the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre and the NIHR Clinical Research Network: Dementias and neurodegeneration (DeNDRoN).
Parkinson's disease is characterised by tremor, slow movement, and stiff and inflexible muscles. It's thought to affect around 1 in 500 people, meaning there are an estimated 127,000 people in the UK with the condition. There is currently no cure for the disease, although there are treatments that can reduce symptoms and maintain quality of life for as long as possible.
Parkinson's disease is caused by the progressive loss of a particular set of nerve cells in the brain, but this damage to nerve cells will have been going on for a long time before symptoms become apparent. If treatments are to be developed that can slow or halt the progression of the disease before it affects people significantly, the researchers say, we need methods to be able to identify people at risk before symptoms take hold.
Conventional MRI cannot detect early signs of Parkinson's, so the Oxford researchers used an MRI technique, called resting-state fMRI, in which people are simply required to stay still in the scanner. They used the MRI data to look at the 'connectivity', or strength of brain networks, in the basal ganglia – part of the brain known to be involved in Parkinson's disease.
The team compared 19 people with early-stage Parkinson's disease while not on medication with 19 healthy people, matched for age and gender. They found that the Parkinson's patients had much lower connectivity in the basal ganglia.
The researchers were able to define a cut-off or threshold level of connectivity. Falling below this level was able to predict who had Parkinson's disease with 100 per cent sensitivity (it picked up everyone with Parkinson's) and 89.5 per cent specificity (it picked up few people without Parkinson's – there were few false positives).
Dr Mackay explains, "Our MRI approach showed a very strong difference in connectivity between those who had Parkinson's disease and those that did not. So much so, that we wondered if it was too good to be true and carried out a validation test in a second group of patients. We got a similar result the second time."
The scientists applied their MRI test to a second group of 13 early-stage Parkinson's patients as a validation of the approach. They correctly identified 11 out of the 13 patients (85 per cent accuracy). " think that our MRI test will be relevant for diagnosis of Parkinson's," says joint lead researcher Dr Michele Hu of the Nuffield Department of Clinical Neurosciences at Oxford University and the Oxford University Hospitals NHS Trust.
"We tested it in people with early-stage Parkinson's. But because it is so sensitive in these patients, we hope it will be able to predict who is at risk of disease before any symptoms have developed. However, this is something that we still have to show in further research." To see if this is the case, the Oxford University researchers are now carrying out further studies of their MRI technique with people who are at increased risk of Parkinson's.
(7 July 2014). Domain-B. MRI Brain Scans Detect People with Early Parkinson's. http://www.domain-b.com/technology/Health_Medicine/20140707_parkinson.html
Recent NewsMay 24 - Survival Rates Differ Widely in Parkinson's, MSA, Lewy Bodies
May 22 - Discovery may offer hope to Parkinson's disease patients
May 15 - Study offers answers on life expectancy for people with Parkinson's disease, Lewy body dementia
May 5 - Parkinson's in a dish: Researchers reproduce brain oscillations
May 5 - ‘Hunger Hormone’ Could Help Treat Parkinson’s Disease
May 3 - Antibiotic doxycycline may offer hope for treatment of Parkinson's disease
May 1 - Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness
Apr 28 - Does Parkinson’s disease begin in the gut?
Apr 28 - New empathy-creating digital device could be revolutionary for caregivers
Apr 24 - Treating Depression With Deep Brain Stimulation Works—Most of the Time
Apr 24 - Parkinson’s disease shows links to depression
Apr 21 - TOLEDO Trial: Apomorphine Infusions Reduce 'Off' Time in Parkinson's Disease
Apr 21 - New drug provides long-awaited breakthrough for Parkinson's psychosis
Apr 12 - Obstructive Sleep Apnea Affects Cognition in Parkinson's Disease
Apr 11 - Seattle boxing gym giving hope to Parkinson's patients
Apr 10 - A new rhythm
Apr 10 - Brain cells reprogrammed to make dopamine, with goal of Parkinson's therapy
Apr 6 - FDA allows marketing of first direct-to-consumer tests that provide genetic risk information for certain conditions
Apr 5 - Combatting the isolation of young onset Parkinson's disease
Apr 1 - The Kid is Alright