NWPF

News ArchivesRead News

More Benefits Found In Deep Brain Stimulation for Parkinson’s

Thursday June 26, 2014

Rick Nauert, PhD

PsychCentral - While it is well-recognized that deep brain stimulation (DBS) improves motor symptoms of patients with early and advanced Parkinson’s disease (PD), new research finds that DBS also reduces the number and severity of non motor symptoms.

“Non-motor features are common in PD patients, occur across all disease stages, and while well-described, are still under-recognized when considering their huge impact on patients’ quality of life,” said Lisa Klingelhoefer, M.D.

For example, DBS of the subthalamic nucleus (STN) is effective for alleviating sleep problems and fatigue associated with PD, producing noticeable long-term improvements in sleep efficiency and the quality and duration of continuous sleep.

DBS also decreases nighttime and early morning dystonia and improves nighttime mobility.

“DBS can contribute to better sleep, less daytime somnolence, improved mobility, and less need for dopamine replacement therapy,” said Klingelhoefer.

Emerging evidence now indicates that DBS can decrease the number and severity of non motor symptoms of patients with Parkinson’s disease (PD) as well, according to a review published in the Journal of Parkinson’s Disease.

However, the effects of DBS on some other non-motor symptoms of PD are less clear-cut, and transient worsening of neuropsychological and psychiatric symptoms have been reported.

For instance, behavioral disorders such as impulsivity (e.g. hypersexuality, pathological gambling, and excessive eating) can occur or worsen in PD patients after STN DBS.

While pre-existing drug-induced psychotic symptoms like hallucinations often disappear after STN DBS, transient psychotic symptoms such as delirium may emerge in the immediate post-operative period.

Similarly, conflicting reports have found that STN DBS improves, worsens, or does not change mood disorders such as depression,mania, or anxiety.

“Further work is required in order to fully understand the mechanisms and impact of DBS of the STN or other brain structures on the non-motor symptoms of PD,” concluded Klingelhoefer.

She suggests that in the future, non-motor symptoms of PD may become an additional primary indication for DBS.

Nauert, Rick PhD. (26 June 2014). More Benefits Found In Deep Brain Stimulation for Parkinson’s. http://psychcentral.com/news/2014/06/26/more-benefits-found-in-deep-brain-stimulation-for-parkinsons/71734.html

Recent News

Jun 22 - A Confused Immune System Could Be Behind Parkinson's Disease
Jun 21 - Predicting cognitive deficits in people with Parkinson’s disease
Jun 13 - Brain Cell Transplants Are Being Tested Once Again For Parkinson's
Jun 12 - Smell Test May Sniff Out Oncoming Parkinson's and Alzheimer's
Jun 8 - Smartphones Track Motor Function in Parkinson's Disease
Jun 8 - GKC Enrolls First Patient in Personal KinetiGraph Trial as Part of NPF’s Parkinson’s Outcomes Project
Jun 8 - Low-fat dairy intake may raise Parkinson's risk
Jun 6 - Patient Voices: Parkinson's Disease
Jun 1 - World-First Trials Have Been Launched to Treat Parkinson's And Blindness With Embryonic Stem Cells
May 24 - Survival Rates Differ Widely in Parkinson's, MSA, Lewy Bodies
May 22 - Discovery may offer hope to Parkinson's disease patients
May 15 - Study offers answers on life expectancy for people with Parkinson's disease, Lewy body dementia
May 5 - Parkinson's in a dish: Researchers reproduce brain oscillations
May 5 - ‘Hunger Hormone’ Could Help Treat Parkinson’s Disease
May 3 - Antibiotic doxycycline may offer hope for treatment of Parkinson's disease
May 1 - Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness
Apr 28 - Does Parkinson’s disease begin in the gut?
Apr 28 - New empathy-creating digital device could be revolutionary for caregivers
Apr 24 - Treating Depression With Deep Brain Stimulation Works—Most of the Time
Apr 24 - Parkinson’s disease shows links to depression