News ArchivesRead News

Researchers identify chemical signature for 'fast' form of Parkinson's

Monday November 25, 2013

The detection of this biomarker could help in early detection of the degenerative disorder, helping doctors plan out a course of treatment to manage the incurable disease.
Ananth Baliga

UPI - Scientists at UCLA and Emory University have identified a biochemical signature in the blood of patients with the faster-progressing form of Parkinson's disease.

Researchers conducted the study using blood samples from 250 Parkinson's patients in the early stages of the disease. Forty were identified as having the slower-progressing Parkinson's and 40 had the faster-progressing form of the degenerative disease.

On comparing the blood samples of these individuals with samples of 20 healthy individuals, they found a potential biomarker called N8-acetyl spermidine, which was significantly elevated in the fast-progressors.

"Such biomarkers reflecting the pathogenesis of Parkinson's are greatly needed due to the fact that the degeneration of the neurons in the brain that produce dopamine -- a hallmark of Parkinson's disease -- is an irreversible process. In addition, that process begins up to 20 to 30 years before imaging can identify any brain changes," said Beate Ritz, a professor at UCLA.

Researchers say the discovery of this biomarker could help in early detection and more effective disease management. Their findings are published online in PLOS ONE.

Parkinson's is a degenerative disorder of the central nervous system. It initially manifests as movement-related problems like shaking, rigidity and slowness of movement, progressing to thinking and behavioral problems later on.

You can read the full scientific journal article at http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0077629

Baliga, A. (25 Nov. 2013). UPI. Researchers identify chemical signature for 'fast' form of Parkinson's. www.upi.com.

Recent News

Nov 22 - A caregiver's story: Living and loving through the slow process of dying
Nov 19 - Testosterone cause of sex differences in the occurrence of Parkinson’s disease, new research suggests
Nov 18 - New strategy reduces side effects in Parkinson's treatment
Nov 14 - Opinion: The never-ending tests of Parkinson's disease
Nov 13 - Parkinson’s disease: A new tool for diagnosis
Nov 10 - Parkinson's Disease Drug May Be Useful For Delaying, Preventing Blindness In Older Population
Nov 9 - Microsoft VP’s diagnosis fuels employees’ heartfelt efforts to help others
Nov 6 - Lewy body dementia: unrecognized and misdiagnosed
Nov 5 - Gait difficulties in Parkinson's linked to new blood vessels in brain
Oct 30 - Special Section: Enabling Technologies for Parkinson’s Disease Management
Oct 27 - Scientists discover a 'switchboard' of molecules that protect against Parkinson's disease
Oct 26 - Dancing improves mobility and quality of life in people with Parkinson's
Oct 23 - The amazing woman who can smell Parkinson’s disease — before symptoms appear
Oct 20 - Personal Essay: The deviousness of dementia
Oct 19 - Mechanism that 'melts' protein clumps may lead to new Parkinson's treatments
Oct 19 - Researchers find that stem cell treatment may reduce cognitive impairment related to dementia with Lewy bodies
Oct 17 - Cancer Drug Helps Parkinson's Patients
Oct 12 - Researchers identify immune gene that can prevent Parkinson's disease and dementia
Oct 12 - Blog Post: An Alert, Well-Hydrated Artist in No Acute Distress
Oct 7 - This month, a brain surgery will be broadcast on live TV for the first time ever