News ArchivesRead News

Researchers identify chemical signature for 'fast' form of Parkinson's

Monday November 25, 2013

The detection of this biomarker could help in early detection of the degenerative disorder, helping doctors plan out a course of treatment to manage the incurable disease.
Ananth Baliga

UPI - Scientists at UCLA and Emory University have identified a biochemical signature in the blood of patients with the faster-progressing form of Parkinson's disease.

Researchers conducted the study using blood samples from 250 Parkinson's patients in the early stages of the disease. Forty were identified as having the slower-progressing Parkinson's and 40 had the faster-progressing form of the degenerative disease.

On comparing the blood samples of these individuals with samples of 20 healthy individuals, they found a potential biomarker called N8-acetyl spermidine, which was significantly elevated in the fast-progressors.

"Such biomarkers reflecting the pathogenesis of Parkinson's are greatly needed due to the fact that the degeneration of the neurons in the brain that produce dopamine -- a hallmark of Parkinson's disease -- is an irreversible process. In addition, that process begins up to 20 to 30 years before imaging can identify any brain changes," said Beate Ritz, a professor at UCLA.

Researchers say the discovery of this biomarker could help in early detection and more effective disease management. Their findings are published online in PLOS ONE.

Parkinson's is a degenerative disorder of the central nervous system. It initially manifests as movement-related problems like shaking, rigidity and slowness of movement, progressing to thinking and behavioral problems later on.

You can read the full scientific journal article at http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0077629

Baliga, A. (25 Nov. 2013). UPI. Researchers identify chemical signature for 'fast' form of Parkinson's. www.upi.com.

Recent News

Oct 2 - A New Attack on Parkinson's Disease
Oct 2 - Antipsychotics for Parkinson's Psychosis May Be Dangerous
Sep 27 - The beginning of the end? The race for a Parkinson’s cure
Sep 23 - Scientists map Parkinson's spread in brain
Sep 22 - Understanding Parkinson's Disease: An Interview with Jon Palfreman
Sep 22 - Living with Lewy Body Dementia
Sep 21 - Adults with autism likely to develop Parkinson’s disease, says study
Sep 16 - Everyday activity more beneficial than occasional strenuous exercise for Parkinson’s disease
Sep 14 - UNC scientists create smarter immune cells to treat Parkinson's disease
Sep 9 - A newly discovered brain disease may point to something disturbing about Alzheimer’s and Parkinson’s
Sep 7 - Treatment for Parkinson's could replace surgery
Sep 4 - Asthma May Influence Risk of Parkinson's Disease
Sep 4 - Researchers Explore Memory Problems Related to Parkinson's
Sep 3 - Press Release: ACADIA Pharmaceuticals Submits New Drug Application for NUPLAZID™ for the Treatment of Parkinson’s Disease Psychosis
Aug 28 - Brain cells 'burn out' in Parkinson's disease
Aug 24 - Study Details Process Involved in Parkinson’s Disease
Aug 24 - Google Reveals Gigantic Ambitions To Fight Cancer, Diabetes, Parkinson's, Heart Problems
Aug 20 - Two proteins work together to help cells eliminate trash; Parkinson's may result
Aug 17 - Scientists visualize critical part of basal ganglia pathways
Aug 17 - VA benefits office seeks all vets exposed to Agent Orange