News ArchivesRead News
Nonmotor Symptoms May Underlie Parkinson's Sleep Complaints
Monday November 25, 2013
medwireNews - In people with Parkinson’s disease (PD), symptoms and comorbidities associated with insomnia differ from those associated with daytime sleepiness, US researchers report.
The team found that nonmotor features such as depression and autonomic symptoms were associated with subjective reports of insomnia, whereas fatigue and dopaminergic medication were associated with sleepiness.
“Our results suggest that clinicians should pay particular attention to uncontrolled non-motor features as potential causes or results of insomnia or daytime sleepiness,” write Seockhoon Chung (University of Michigan, Ann Arbor) and colleagues in the Journal of Clinical Sleep Medicine.
The team assessed 128 PD patients for insomnia, sleepiness, fatigue, disease severity, depression, and autonomic symptoms; 38 of the participants also underwent nocturnal polysomnography and sleep latency testing.
The mean age of participants was 65.7 years, 75% were men, and the mean duration of PD was 5.9 years.
Multivariate logistic regression analysis showed that the severity of nonmotor symptoms, rather than motor symptoms, was primarily associated with subjective insomnia at an odds ratio (OR) of 2.58 per standard deviation increase on the Unified Parkinson Disease Rating Scale part I. Increasing severity of depressive symptoms (OR=1.79) autonomic symptoms (OR=1.77), and fatigue (OR=1.19) all independently predicted insomnia severity, as did younger age (OR=0.61).
Meanwhile, two factors predicted the severity of sleepiness: levodopa-equivalent medication dosage (OR=1.74) and fatigue severity (OR=1.14).
Among the subset of people who underwent polysomnography, both sleep latency and sleep efficiency correlated with autonomic symptoms. Also, 74% of patients had obstructive sleep apnea, and scores on the apnea-hypopnea index correlated with daytime sleepiness.
Chung and co-authors conclude that clinicians should routinely assess PD patients for sleepiness and fatigue using subjective rating scales. Laboratory-based sleep studies may also be informative if obstructive sleep apnea is suspected, they add.
Lyford, J. (25 Nov. 2013). medwireNews. Nonmotor symptoms may underlie Parkinson's sleep complaints. www.news-medical.net.
Recent NewsMay 24 - Survival Rates Differ Widely in Parkinson's, MSA, Lewy Bodies
May 22 - Discovery may offer hope to Parkinson's disease patients
May 15 - Study offers answers on life expectancy for people with Parkinson's disease, Lewy body dementia
May 5 - Parkinson's in a dish: Researchers reproduce brain oscillations
May 5 - ‘Hunger Hormone’ Could Help Treat Parkinson’s Disease
May 3 - Antibiotic doxycycline may offer hope for treatment of Parkinson's disease
May 1 - Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness
Apr 28 - Does Parkinson’s disease begin in the gut?
Apr 28 - New empathy-creating digital device could be revolutionary for caregivers
Apr 24 - Treating Depression With Deep Brain Stimulation Works—Most of the Time
Apr 24 - Parkinson’s disease shows links to depression
Apr 21 - TOLEDO Trial: Apomorphine Infusions Reduce 'Off' Time in Parkinson's Disease
Apr 21 - New drug provides long-awaited breakthrough for Parkinson's psychosis
Apr 12 - Obstructive Sleep Apnea Affects Cognition in Parkinson's Disease
Apr 11 - Seattle boxing gym giving hope to Parkinson's patients
Apr 10 - A new rhythm
Apr 10 - Brain cells reprogrammed to make dopamine, with goal of Parkinson's therapy
Apr 6 - FDA allows marketing of first direct-to-consumer tests that provide genetic risk information for certain conditions
Apr 5 - Combatting the isolation of young onset Parkinson's disease
Apr 1 - The Kid is Alright