News ArchivesRead News
Mouse Model of Parkinson's Disease Shows Improved Brain Function, Motor Skills
Wednesday October 16, 2013
The Sacramento Bee - A paper published in the Journal of Neuroimmune Pharmacology shows that Revalesio's novel therapeutic RNS60 significantly improved biochemical and behavioral (movement) outcomes in a mouse model of Parkinson's disease (PD). The research was conducted by the laboratory of Dr. Kalipada Pahan at Rush University Medical Center.
The model used in the study generates Parkinson's-like symptoms through targeting dopaminergic neurons in the substantia nigra pars compacta, a region of the brain involved in controlling movement. The model produces neuronal death, loss of dopamine, and physical symptoms of the disease. The experiments conducted by Dr. Pahan's group demonstrate that treatment with RNS60 restored dopamine and provided a significant level of protection against neuronal death through upregulation of a protein called I kappa B alpha (IkBa).
"IkBa is an anti-inflammatory protein that helps with survival and function of neurons in neuroinflammatory conditions," said Dr. Pahan. "For therapeutic purpose, the best option would be to increase the level of this protein directly in the brain using a non-toxic medication. Remarkably, RNS60 treatment achieved this goal and thereby protected dopaminergic neurons in the mouse model of PD," Dr. Pahan said.
In addition to protecting the brain from the biochemical damage associated with PD, RNS60 also preserved the motor function of the animals, which the researchers assessed using numerous techniques. The ability to protect dopaminergic neurons, preserve striatal neurotransmitter function, and halt the progression of neurodegeneration and associated symptoms strongly suggest RNS60 as a promising therapeutic for PD and other neuroinflammatory diseases.
Revalesio's director of neurology research, Dr. Supurna Ghosh said, "In this study, RNS60's effect on the central anti-inflammatory mechanism in the glial cells of the brain is remarkable. Based on this work, and research previously published, we are hopeful RNS60 can have significant therapeutic effects in multiple neuroinflammatory and neuro-degenerative diseases. We are moving forward with additional research and human trials to further understand the therapeutic potential of RNS60."
A copy of the paper, Protection of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease by a Physically-Modified Saline Containing Charge-Stabilized Nanobubbles, can be found online at the Journal of Neuroimmune Pharmacology. (http://link.springer.com/article/10.1007/s11481-013-9503-3)
About RNS60: Revalesio is developing the use of RNS60 as a therapeutic that alters whole cell conductance through effects voltage-sensing membrane-bound proteins, thereby modulating the activity of G protein-coupled receptors and the secretion of cytokines, chemokines resulting in decreased inflammation and cell death. RNS60 contains charge-stabilized nanostructures (CSN) that are created by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow. RNS60 has demonstrated a reduction in inflammatory responses that are linked to numerous diseases, including neurodegenerative, respiratory and cardiovascular diseases.
(16 Oct. 2013). The Sacramento Bee. Mouse Model of Parkinson's Disease Shows Improved Brain Function, Motor Skills Due to Revalesio's RNS60. www.sacbee.com.
Recent NewsMay 24 - Survival Rates Differ Widely in Parkinson's, MSA, Lewy Bodies
May 22 - Discovery may offer hope to Parkinson's disease patients
May 15 - Study offers answers on life expectancy for people with Parkinson's disease, Lewy body dementia
May 5 - Parkinson's in a dish: Researchers reproduce brain oscillations
May 5 - ‘Hunger Hormone’ Could Help Treat Parkinson’s Disease
May 3 - Antibiotic doxycycline may offer hope for treatment of Parkinson's disease
May 1 - Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness
Apr 28 - Does Parkinson’s disease begin in the gut?
Apr 28 - New empathy-creating digital device could be revolutionary for caregivers
Apr 24 - Treating Depression With Deep Brain Stimulation Works—Most of the Time
Apr 24 - Parkinson’s disease shows links to depression
Apr 21 - TOLEDO Trial: Apomorphine Infusions Reduce 'Off' Time in Parkinson's Disease
Apr 21 - New drug provides long-awaited breakthrough for Parkinson's psychosis
Apr 12 - Obstructive Sleep Apnea Affects Cognition in Parkinson's Disease
Apr 11 - Seattle boxing gym giving hope to Parkinson's patients
Apr 10 - A new rhythm
Apr 10 - Brain cells reprogrammed to make dopamine, with goal of Parkinson's therapy
Apr 6 - FDA allows marketing of first direct-to-consumer tests that provide genetic risk information for certain conditions
Apr 5 - Combatting the isolation of young onset Parkinson's disease
Apr 1 - The Kid is Alright