NWPF

News ArchivesRead News

Higher Iron Levels in Blood May Protect Against Parkinson's Disease

Tuesday June 04, 2013

Christine Hsu

Counsel & Heal - A new study has found an association between higher iron levels and lower risk of developing Parkinson's disease.

The latest research, published in the journal PLOS Medicine, looked at whether there was a link between serum iron levels and the risk of Parkinson's disease.

The causes of Parkinson's disease are currently unknown. However, previous studies have revealed that Parkinson's patients have lower blood levels of iron.

In the new study, scientists estimated the effect of blood iron levels on the risk of Parkinson's disease by looking at three polymorphisms in two genes, HFE and TMPRSS6. Polymorphism occurs when two or more clearly different phenotypes exist in the same population of a species.

Researchers performed a meta-analysis combining the results of studies investigating the genetic effect on iron levels and a meta-analysis of studies investigating the genetic effect on the risk of Parkinson´s disease for each polymorphism.

Afterwards, investigators performed three separate Mendelian randomization analyses to estimate the effect of iron on Parkinson disease for the three polymorphisms.

The findings revealed a statistically significant odds ratio of 0.97 for Parkinson's disease per 10 μg/dl increase in iron, corresponding to a 3% reduction in the risk of Parkinson´s disease for every 10 μg/dl increase in blood iron.

Researchers explained that because genotype influences on blood levels represent difference that generally persist throughout adult life, the latest findings reflects an effect of iron over the course of a lifetime.

Investigators said the latest findings suggest that increased iron levels in the bloos are associated with a 3 percent relative reduction in the risk of Parkinson's diease for every 10 μg/dl increase in iron.

Study authors conclude that increased blood iron levels may have a protective effect against Parkinson's disease.

Recent News

May 20 - Book Review: Aging in the Key of Humor
May 19 - Press Release: The Michael J. Fox Foundation for Parkinson's Research Joins Multinational Critical Path for Parkinson's Consortium
May 19 - Congress reaches deal to overhaul chemical regulation
May 16 - Lifestyle: Why Parkinson's disease won't stop me rowing across the Pacific
May 16 - Many biomarkers for PD fail to inform on progression
May 10 - Parkinson's Cell Transplant Shows Good Reinnervation at 24 Years
May 7 - Growing art installation gathers stories of living with Parkinson's
May 5 - New technique can provide better cell transplants against Parkinson's disease
May 2 - What's Good For The Heart Is Good For The Brain
Apr 29 - Press Release: FDA approves first drug to treat hallucinations and delusions associated with Parkinson’s disease
Apr 28 - Dopamine-making neurons can be chemically controlled in animal model of Parkinson's
Apr 25 - Lifestyle: Dating with Disease
Apr 25 - Scientific breakthrough in fight against Parkinson's and Alzheimer's
Apr 20 - Breakthrough Parkinson's disease blood test
Apr 15 - Living with Parkinson's
Apr 12 - Tissue biomarker for dementia with Lewy bodies and Parkinson’s disease
Apr 11 - Yoga for Every Body: Experts say yoga can ease pain and improve mobility for people with neurologic conditions
Apr 9 - Commonly prescribed Parkinson's drugs up risk of compulsive gambling, shopping, binge eating, hypersexuality
Apr 7 - Pfizer and IBM Launch Innovative Research Project to Transform Parkinson's Disease Care
Apr 7 - Parkinson's Drug Highly Effective for Resistant Depression