NWPF

News ArchivesRead News

Immune cells contribute to the development of Parkinson's disease

Thursday December 25, 2008

EurekAlert - Parkinson disease is a neurodegenerative disorder that impairs movement, balance, speech, and other functions. It is characterized by the loss of nerves in the brain that produce a substance known as dopamine.

Although the loss of dopamine-containing nerves is accompanied by accumulation of immune cells known as T cells, these accumulating T cells were not thought to have a role in the development of disease.

However, Stéphane Hunot, Etienne C. Hirsch, and colleagues, at INSERM UMR 679, France, have now shown that CD4+ T cells make a significant contribution to the development of disease in a mouse model of Parkinson disease.

In the study, a substantial number of CD4+ T cells and CD8+ T cells were observed to have accumulated in postmortem brain tissue from individuals with Parkinson disease and mice with a Parkinson-like disease.

Importantly, mice lacking all T cells developed substantially less severe disease in the mouse model of Parkinson disease. Further analysis indicated that protection was specifically associated with a lack of CD4+ T cells expressing the protein FasL.

The authors therefore suggest that targeting the immune system might provide a new therapeutic approach to treating Parkinson disease. However, in an accompanying commentary, Stanley Appel, at Methodist Neurological Institute, Houston, warns that although these data provide rationale for immune-based strategies, there are a large number of questions that need to be answered before such approaches can be considered in the clinic.

Recent News

May 2 - What's Good For The Heart Is Good For The Brain
Apr 29 - Press Release: FDA approves first drug to treat hallucinations and delusions associated with Parkinson’s disease
Apr 28 - Dopamine-making neurons can be chemically controlled in animal model of Parkinson's
Apr 25 - Lifestyle: Dating with Disease
Apr 25 - Scientific breakthrough in fight against Parkinson's and Alzheimer's
Apr 20 - Breakthrough Parkinson's disease blood test
Apr 12 - Tissue biomarker for dementia with Lewy bodies and Parkinson’s disease
Apr 11 - Yoga for Every Body: Experts say yoga can ease pain and improve mobility for people with neurologic conditions
Apr 9 - Commonly prescribed Parkinson's drugs up risk of compulsive gambling, shopping, binge eating, hypersexuality
Apr 7 - Pfizer and IBM Launch Innovative Research Project to Transform Parkinson's Disease Care
Apr 7 - Parkinson's Drug Highly Effective for Resistant Depression
Apr 5 - Speech therapy program helps Parkinson’s patients regain speaking ability
Apr 4 - New research maps out pesticide exposure and Parkinson's disease in Nebraska
Apr 4 - The rogue immune cells that wreck the brain
Mar 28 - Chemists identify structure of protein that forms fibrils in Parkinson's patients
Mar 25 - UPDATE 1-FDA staff says Acadia's drug for Parkinson's disease psychosis is effective
Mar 23 - The virus that could cure Alzheimer's, Parkinson's and more
Mar 21 - Antipsychotic drugs may do significantly more harm to Parkinson's disease patients
Mar 21 - Rosacea Might Boost Parkinson's Risk: Study
Mar 21 - Apple CareKit Could Completely Change What It's Like To Live With Parkinson's Disease & Epilepsy