NWPF

News ArchivesRead News

Pesticides exposure associated with Parkinson’s disease

Wednesday December 27, 2006

12/27/06(Harvard School of Public Health) - In the first large-scale, prospective study to examine possible links between chronic, low-dose exposure to pesticides and Parkinson’s disease ( PD ), researchers at the Harvard School of Public Health ( HSPH ) have shown that individuals reporting exposure to pesticides had a 70 percent higher incidence of Parkinson’s disease than those not reporting exposure. No increased risk of Parkinson’s disease was found from reported exposure to other occupational hazards, including asbestos, coal or stone dust, chemicals, acids, or solvents.

The study is published in the Annals of Neurology.

Previous studies had suggested a link between Parkinson’s disease and low-level exposure to pesticides, though the data remains inconclusive. The researchers, led by Alberto Ascherio, at HSPH, looked at data from the Cancer Prevention Study II Nutrition Cohort, a prospective study begun in 1992 by the American Cancer Society. Some 143,325 participants who responded to a follow-up survey in 2001 were included in the HSPH study. Researchers then contacted those individuals in the 2001 survey who reported a diagnosis of Parkinson’s disease to ask if their medical records could be reviewed to confirm the diagnosis. Ultimately, Ascherio and his colleagues included in their study a total of 413 cases of Parkinson’s disease with onset of symptoms and diagnosis after 1992.

The researchers used exposure data collected in 1982 from the CPS II mortality study, a study from which the Nutrition Cohort was drawn. Exposure to pesticides was reported by 5,203 men ( 8.2 percent ) and 2,661 women ( 3.3 percent ). Among those reporting exposure, after adjusting for age, sex, and other risk factors for Parkinson’s disease, there was a 70 percent higher incidence of Parkinson’s disease than among people who reported no exposure. Those reporting exposure were more likely to be male than female to report their occupation as farmer, rancher or fisherman and to be blue-collar workers, but none of these factors could account for the increased risk of Parkinson’s disease, which was similar in men or women, and in non-farmers as well as farmers. The significant association between pesticide exposure and Parkinson’s disease among individuals who are not farmers is most likely explained by use of pesticides at home or in gardening.

Future studies will need to examine which specific pesticides or classes of pesticides are likely to cause Parkinson’s disease.

Recent News

Oct 17 - Scientists Identify Structure of PINK1, Key Parkinson’s-protective Protein
Oct 17 - Diabetes drug cuts Parkinson's risk by 28 percent, study finds
Oct 10 - Advances in Brain Pacemaker Reduces Tremors, Helps Parkinson's Sufferers Live a More Normal Life
Oct 10 - Medical History Could Help Predict Parkinson's Disease Risk Long Before Diagnosis
Oct 3 - Changes in Olfactory Bulb Explain Loss of Smell in Early Stages of Parkinson’s Disease, Study Finds
Oct 3 - Sleep Disturbances May Worsen Motor Symptoms in Parkinson’s Disease, Study Suggests
Sep 12 - Australian Researchers Develop New Diagnostic Tool to Spot Early Signs of Parkinson’s
Sep 11 - GeneFo Webinar to Focus on Using Humor to Manage Parkinson’s Disease
Sep 6 - Parkinson’s and the ‘D’ word
Sep 6 - Compounds in Asthma Drugs Might Be Used as Parkinson’s Treatment
Sep 5 - AstraZeneca Joins Takeda, Berg to Advance Development of Parkinson’s Disease Therapies
Sep 1 - Stem Cell Transplant Trial in Parkinson’s Patients Planned After Test in Japan Succeeds in Monkeys
Sep 1 - Titan to Start Phase 1/2 Study of Subdermal Implant to Deliver Requip to Parkinson’s Patients
Aug 30 - FDA Refuses Acorda’s Inbrija New Drug Application Due to Manufacturing Questions
Aug 23 - Support Groups: Are They for You?
Aug 22 - Internet Visits with Parkinson’s Specialist Can Be as Effective as In-person Visits, Trial Finds
Aug 21 - Cavion’s New CMO to Lead Cav3 Platform Development for Neurological Diseases
Aug 15 - Singing Helps Early-stage Parkinson’s Patients Retain Speech, Respiratory Control, Studies Show
Aug 14 - 16 Tips to Increase Your Mobility Confidence While Living With Parkinson’s Disease
Aug 10 - Boxers are fighting back against Parkinson’s