News ArchivesRead News
Novelty-Seeking Traits Found Frequently in Screening Parkinson’s Disease Patients: Presented at ANA
Thursday October 19, 2006
October 11, 2006(Doctor’s Guide) - Compulsive behaviors -- especially traits of novelty seeking -- appear to be a common occurrence in individuals with Parkinson’s disease, according to research presented here at the American Neurological Association (ANA) 131st Annual Meeting.
"Although dopaminergic medication has been implicated in the development of compulsive behaviors, underlying personality traits such as novelty seeking may be significant risk factors for the development of these behaviors," said Jennifer Hui, MD, assistant professor of neurology, Keck School of Medicine, University of Southern California, Los Angeles, California.
There have been reports of compulsive gambling and hypersexuality among patients taking the newer dopamine agonists. To confirm the presence of a link, Dr. Hui and colleagues screened 48 patients with Parkinson’s disease.
They identified 13 individuals (27.1%) as having compulsive behaviors. In these patients, the researchers were able to distinguished a total of 29 compulsive behaviors.
"Three of these people had 4 different behaviors, and 1 person was identified with 5 different compulsive behaviors," Dr. Hui said at her poster presentation October 10th.
However, her team could not distinguish whether these behaviors existed before disease onset, as a consequence of the disease or as a consequence of treatment with dopamine agonists. "That, of course, is the big picture," she said.
She cautioned that jumping to the conclusion that the behaviors are modulated by the drugs may prove to be inaccurate. "We need further studies to figure that out," she said.
Her findings did determine that compulsive behavior is associated with younger patients with Parkinson’s disease. In her study, patients without compulsive behaviors averaged 75 years of age, while those with compulsive behaviors averaged 62 years of age. That age differential was highly statistically significant.
She also determined that those with compulsive behaviors had been diagnosed with Parkinson’s disease for a longer period of time -- 6.5 years on average versus 3 years on average for those who did not have these behaviors.
Patients identified with compulsive behaviors also tended to be more likely to express novelty-seeking traits (P = .009). The patients with compulsive behaviors were more likely to score higher on the Beck Depression Inventory as well.
However, the researchers did not find a significant correlation between use of dopamine agonists and compulsive behavior.
Recent NewsSep 12 - Australian Researchers Develop New Diagnostic Tool to Spot Early Signs of Parkinson’s
Sep 11 - GeneFo Webinar to Focus on Using Humor to Manage Parkinson’s Disease
Sep 6 - Parkinson’s and the ‘D’ word
Sep 6 - Compounds in Asthma Drugs Might Be Used as Parkinson’s Treatment
Sep 5 - AstraZeneca Joins Takeda, Berg to Advance Development of Parkinson’s Disease Therapies
Sep 1 - Stem Cell Transplant Trial in Parkinson’s Patients Planned After Test in Japan Succeeds in Monkeys
Sep 1 - Titan to Start Phase 1/2 Study of Subdermal Implant to Deliver Requip to Parkinson’s Patients
Aug 30 - FDA Refuses Acorda’s Inbrija New Drug Application Due to Manufacturing Questions
Aug 23 - Support Groups: Are They for You?
Aug 22 - Internet Visits with Parkinson’s Specialist Can Be as Effective as In-person Visits, Trial Finds
Aug 21 - Cavion’s New CMO to Lead Cav3 Platform Development for Neurological Diseases
Aug 15 - Singing Helps Early-stage Parkinson’s Patients Retain Speech, Respiratory Control, Studies Show
Aug 14 - 16 Tips to Increase Your Mobility Confidence While Living With Parkinson’s Disease
Aug 10 - Boxers are fighting back against Parkinson’s
Aug 9 - Parkinson’s Experiment to Be Aboard Next Flight to International Space Station
Aug 9 - Parkinson’s Disease and Sleeping with the Enemy
Aug 7 - The Importance of Oral Health in Parkinson’s Disease
Aug 7 - Researchers Gain Better Insight Into Alpha-Synuclein’s Role in Parkinson’s Disease
Jul 31 - New Digital Cognitive Assessment Tool Receives Positive FDA Review
Jul 20 - Parkinson’s DREAM Challenge Uses Mobile Sensor Data to Monitor Health Based on Movement