NWPF

News ArchivesRead News

Memory gene discovery holds promise for Alzheimer’s and Parkinson’s cure

Thursday October 26, 2006

October 20, 2006 (SAWF News) - In what is being termed as a breakthrough in medical science, the discovery of a gene linked to human memory may pave the way for developing new medicines for diseases such as Alzheimer’s and Parkinson’s.

Researchers at the Translational Genomics Research Institute (TGen) in Phoenix, Arizona have used the Affymetrix 500K Array to discover a gene called Kibra, which is associated with memory performance in humans, and will help scientists better understand human memory functions.

The study entitled, ‘Common KIBRA alleles are associated with human memory performance,’ will be published in the latest issue of Science.

"Using the latest Affymetrix 500K Array, we have shed light on the fundamental biological process of human memory performance," said Dr. Dietrich Stephan, director of TGen’s Neurogenomics Division.

"We can use this new understanding to develop drugs that will improve memory function," Dr. Stephen added.

Until now researchers did not have access to the high-density technology needed to examine the genetic components associated with memory performance.

But the team at TGen used Affymetrix Human Mapping 500K Arrays to analyze 500,000 DNA markers simultaneously, providing a genetic blueprint for the memory-study participants.

The researchers discovered the Kibra gene by comparing the genetic blueprints of people with good memory vs. poor memory and looking for the genetic variations consistently present in one group, but not the other. They then validated their discovery by replicating the Kibra gene finding in two separate and distinct groups of subjects.

"This memory study is a perfect example of how the use of advanced technologies in human genetics yields fundamental discoveries," said Stephen P.A. Fodor, Ph.D., chairman and CEO at Affymetrix. (ANI)

Recent News

Aug 22 - Parkinson's Disease Could Be Diagnosed Through Eye Check, Mice Help Researchers In Further Study
Aug 22 - Machine learning to unlock Parkinson's disease mystery
Aug 21 - Cognitive control plays major role in Parkinson’s Gait
Aug 15 - 'I've Never Felt Constrained': After Parkinson's Diagnosis, Chestnut Hill Man Turns To Drumming
Aug 11 - Virtual reality and treadmill training could help prevent falls in older adults
Aug 9 - New laboratory model replicates early phase of Parkinson's before onset of motor symptoms
Aug 8 - Marshall University Scientists Develop A New Approach For Parkinson’s Disease Therapy
Aug 5 - Cambuslang woman diagnosed with Parkinson's at 42 is set to trek through Alps
Aug 4 - Active Music Therapy May Be Beneficial in Parkinson's
Aug 1 - Mini-Brains? Scientists Grow Rice Grain-Sized Brains to Aid Parkinson’s Research
Jul 30 - Lab method sheds light on how genetic mutations cause inherited Parkinson's disease
Jul 27 - Indicators of Parkinson's disease risk found in unexpected places
Jul 24 - Parkinson's: Mutant gene interaction may pave the way for new treatments
Jul 22 - Boxing training used to fight against Parkinson's disease
Jul 17 - Stem cell treatment breakthrough could cure Parkinson’s patients
Jul 14 - Cancer drug shows early promise for Parkinson's disease
Jul 13 - Opinion: Dividing the Caregiving Responsibilities Between Siblings
Jul 12 - Researchers make advance in possible treatments for Gaucher, Parkinson’s diseases
Jul 11 - Parkinson’s Head Trauma Link Looks Even Stronger
Jul 7 - Penn students’ start-up XEED puts wearables to work against Parkinson’s disease