News ArchivesRead News
Parkinson’s patients stomach new drug better than conventional meds
Thursday June 15, 2006
12 June 2006(Baylor College of Medicine) - Several studies conducted at Baylor College of Medicine (BCM) in Houston show that a new kind of orally disintegrating tablets provides improved symptom relief for patients with Parkinson’s disease. Results are reported in today’s issue of the journal Therapy.
A new form of the medication selegiline, used for years to manage motor complications in Parkinson’s patients, avoids first-pass metabolism and sidesteps compromises to its efficacy and tolerability. The drug is currently awaiting U.S. Food and Drug Administration approval for use as an adjunctive therapy to the drug levodopa in the management of the neurodegenerative disease.
“Although a variety of therapeutic options exist, there is a tremendous amount of unmet need in the treatment of Parkinson’s disease,” said co-author Dr. Joseph Jankovic, professor of neurology at BCM and director of the college’s Parkinson’s Disease Center and Movement Disorders Clinic. “
Many patients with Parkinson’s disease still experience several hours a day during which the effects of levodopa, the most frequently used drug in Parkinson’s treatment, wear off to the extent that patients shake and cannot move. Besides the wearing-off effects, many patients experience jerky involuntary movements, called dyskinesias, at the peak effect of levodopa.
Because the orally disintegrating tablet dissolves within seconds, the drug can be delivered more effectively at a relatively low dose, reducing roughly two hours each day that a patient experiences debilitating symptoms, according to the studies’ findings.
“The goal of treatment is to reduce the ‘off’ time and increase the ‘on’ time during which they are free from Parkinson’s symptoms and dyskinesia,” said Jankovic. “This unique formulation of selegiline delivers a more active drug without some of the troublesome side effects seen with standard selegiline. These study results offer hope to Parkinson’s disease patients and the physicians who treat them.”
Due to its fast-dissolving technology, the new form of selegiline bypasses the gut and first-pass hepatic metabolism and is primarily absorbed into the systemic circulation through the oral mucosa, the mucous membrane that covers all structures inside the mouth except the teeth.
Some Parkinson’s patients also have difficulty swallowing, making this treatment a more convenient option than others. One of the studies reports that more than 90 percent of patients found the new selegiline easy to take, with 61 percent rating it extremely easy to take.
The Therapy article draws from results of three selegiline studies, whose patient populations totaled 517. BCM was one several international sites that participated. Dr. Anthony Clarke of the United Kingdom-based Amarin Neuroscience was a co-author of the paper.
Recent NewsDec 8 - New technique scours the genome for genes that combat disease
Dec 8 - Restless sleep may be an early sign of Parkinson's, dementia
Dec 1 - Defects in cell's 'waste disposal system' linked to Parkinson's
Dec 1 - Dual virtual reality/treadmill exercises promote brain plasticity in Parkinson's patients
Nov 17 - 'Moving Day' participant is not letting young-onset Parkinson's disease stop him
Nov 17 - Focused ultrasound shows promise for treating Parkinson's tremor
Nov 17 - New research to target air pollution as a potential trigger for Parkinson’s
Nov 17 - This device will let you feel what it's like to suffer from Parkinson's
Nov 10 - How does Parkinson's disease influence depression?
Nov 10 - House votes to repeal ObamaCare's Medicare cost-cutting board
Nov 10 - Microsoft shows off watch that quiets Parkinson's tremors
Nov 3 - Utah group battling Parkinson's disease with boxing
Nov 3 - UVA-LED STUDY EXAMINES POTENTIAL OF SOUND WAVES TO MANAGE PARKINSON’S DISEASE
Oct 27 - Herbicide's link to Parkinson's disease
Oct 27 - NTU Singapore, KAIST scientists discover new mechanism that causes Parkinsonian symptoms
Oct 27 - 70,000 Washingtonians face higher insurance costs after Trump order, officials say
Oct 18 - Brain disconnections may contribute to Parkinson's hallucinations
Oct 18 - Fighting Parkinson's disease through dance
Oct 17 - Scientists Identify Structure of PINK1, Key Parkinson’s-protective Protein
Oct 17 - Diabetes drug cuts Parkinson's risk by 28 percent, study finds