News ArchivesRead News
Scientists close in on genes responsible for Parkinson’s disease
Tuesday December 27, 2005
27 Dec 2005(Health Channel) - Scientists have identified 570 genes that act abnormally during the development of Parkinson’s disease, a finding which could help doctors predict the likelihood of it developing.
The research published in Neurogenetics, by the team from Imperial College London (ICL) and the University of Liege, Belgium, uses microarrays to analyse brains from Parkinson’s patients.
Microarrays are laboratory chips able to pick out which genes are active when different processes are occurring in the brain.
When they analysed brains from people with Parkinson’s, they found that out of all 25,000 human genes, regulation of 570 was highly abnormal in Parkinson’s brains compared with non-diseased brains.
The researchers analysed 23 brains from recently deceased patients, 15 affected by Parkinson’s and 8 control brains.
"This research shows there are a considerable number of genes associated with the development of Parkinson’s, potentially providing new clues for how to treat this disease," said Dr Linda Moran from Imperial College London and one of the authors of the paper.
"Now that we can identify these genes it may be possible to develop new therapies to help the increasing numbers of Parkinson’s patients."
The team, led by Professor Manuel Graeber, analysed two parts of the brain which are affected by neurodegeneration in Parkinson’s - the substantia nigra in the mid-brain, and the cerebral cortex.
They were able to eliminate around 15,000 genes from any role in Parkinson’s, as they were not found to be active in the substantia nigra, the part of the brain most affected by Parkinson’s.
The study was funded by the UK Parkinson’s Disease Society.
Recent NewsSep 12 - Australian Researchers Develop New Diagnostic Tool to Spot Early Signs of Parkinson’s
Sep 11 - GeneFo Webinar to Focus on Using Humor to Manage Parkinson’s Disease
Sep 6 - Parkinson’s and the ‘D’ word
Sep 6 - Compounds in Asthma Drugs Might Be Used as Parkinson’s Treatment
Sep 5 - AstraZeneca Joins Takeda, Berg to Advance Development of Parkinson’s Disease Therapies
Sep 1 - Stem Cell Transplant Trial in Parkinson’s Patients Planned After Test in Japan Succeeds in Monkeys
Sep 1 - Titan to Start Phase 1/2 Study of Subdermal Implant to Deliver Requip to Parkinson’s Patients
Aug 30 - FDA Refuses Acorda’s Inbrija New Drug Application Due to Manufacturing Questions
Aug 23 - Support Groups: Are They for You?
Aug 22 - Internet Visits with Parkinson’s Specialist Can Be as Effective as In-person Visits, Trial Finds
Aug 21 - Cavion’s New CMO to Lead Cav3 Platform Development for Neurological Diseases
Aug 15 - Singing Helps Early-stage Parkinson’s Patients Retain Speech, Respiratory Control, Studies Show
Aug 14 - 16 Tips to Increase Your Mobility Confidence While Living With Parkinson’s Disease
Aug 10 - Boxers are fighting back against Parkinson’s
Aug 9 - Parkinson’s Experiment to Be Aboard Next Flight to International Space Station
Aug 9 - Parkinson’s Disease and Sleeping with the Enemy
Aug 7 - The Importance of Oral Health in Parkinson’s Disease
Aug 7 - Researchers Gain Better Insight Into Alpha-Synuclein’s Role in Parkinson’s Disease
Jul 31 - New Digital Cognitive Assessment Tool Receives Positive FDA Review
Jul 20 - Parkinson’s DREAM Challenge Uses Mobile Sensor Data to Monitor Health Based on Movement