News ArchivesRead News
Scientists close in on genes responsible for Parkinson’s disease
Tuesday December 27, 2005
27 Dec 2005(Health Channel) - Scientists have identified 570 genes that act abnormally during the development of Parkinson’s disease, a finding which could help doctors predict the likelihood of it developing.
The research published in Neurogenetics, by the team from Imperial College London (ICL) and the University of Liege, Belgium, uses microarrays to analyse brains from Parkinson’s patients.
Microarrays are laboratory chips able to pick out which genes are active when different processes are occurring in the brain.
When they analysed brains from people with Parkinson’s, they found that out of all 25,000 human genes, regulation of 570 was highly abnormal in Parkinson’s brains compared with non-diseased brains.
The researchers analysed 23 brains from recently deceased patients, 15 affected by Parkinson’s and 8 control brains.
"This research shows there are a considerable number of genes associated with the development of Parkinson’s, potentially providing new clues for how to treat this disease," said Dr Linda Moran from Imperial College London and one of the authors of the paper.
"Now that we can identify these genes it may be possible to develop new therapies to help the increasing numbers of Parkinson’s patients."
The team, led by Professor Manuel Graeber, analysed two parts of the brain which are affected by neurodegeneration in Parkinson’s - the substantia nigra in the mid-brain, and the cerebral cortex.
They were able to eliminate around 15,000 genes from any role in Parkinson’s, as they were not found to be active in the substantia nigra, the part of the brain most affected by Parkinson’s.
The study was funded by the UK Parkinson’s Disease Society.
Recent NewsJan 16 - January 16, 2018 News Update
Jan 9 - January 9, 2018 News Update
Jan 2 - January 2, 2018 News Update
Dec 26 - December 26, 2017 News Update
Dec 19 - December 19, 2017 News Update
Dec 8 - New technique scours the genome for genes that combat disease
Dec 8 - Restless sleep may be an early sign of Parkinson's, dementia
Dec 1 - Defects in cell's 'waste disposal system' linked to Parkinson's
Dec 1 - Dual virtual reality/treadmill exercises promote brain plasticity in Parkinson's patients
Nov 17 - 'Moving Day' participant is not letting young-onset Parkinson's disease stop him
Nov 17 - Focused ultrasound shows promise for treating Parkinson's tremor
Nov 17 - New research to target air pollution as a potential trigger for Parkinson’s
Nov 17 - This device will let you feel what it's like to suffer from Parkinson's
Nov 10 - How does Parkinson's disease influence depression?
Nov 10 - House votes to repeal ObamaCare's Medicare cost-cutting board
Nov 10 - Microsoft shows off watch that quiets Parkinson's tremors
Nov 3 - Utah group battling Parkinson's disease with boxing
Nov 3 - UVA-LED STUDY EXAMINES POTENTIAL OF SOUND WAVES TO MANAGE PARKINSON’S DISEASE
Oct 27 - Herbicide's link to Parkinson's disease
Oct 27 - NTU Singapore, KAIST scientists discover new mechanism that causes Parkinsonian symptoms